Simultaneous effect of quercetin and exercises on oxidative stress induced by colon cancer in the heart tissue of rats

Introduction: Colon cancer is the fourth cause of mortality at the world and second common cancer in the Europe. About 8% of all cancer deaths are due to colon cancer. This condition is caused by abnormal growth of cells which can invade or multiply in other tissues of the body (metastasis). The present study was designed to investigate the Simultaneous effect of quercetin and exercises on oxidative stress induced by colon cancer In the heart tissue in animal models. Materials and Methods: In this experimental study a total of 80 rats were divided into two groups, including control (n=10) and treated group (n=70). Cancer in rats is induced by subcutaneous injection of azoxy methane and then the cancer rats were randomly divided into seven experimental groups including, patient, saline, quercetin, continuous exercise, interval exercise, continuous exercise with quercetin, and interval exercise with quercetin. Oxidative stress including superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) were measured in the heart tissue using specific ELISA kits. Data were analyzed using ANOVA program by SPSS software. Results: Quercetin supplementation alone or in combination with exercise trainings significantly increased the mean of cardiac CAT and SOD activity compared to the treated group and saline groups (p<0.001), while MDA level was significantly decreased (p<0.05). Conclusions: Colon cancer increases the oxidative stress of heart cells. Although quercetin alone has an anti-oxidative properties, combined therapy with interval and continuous training can be probably more effective.